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Ghost Imaging Speeds Up Super-Resolution Microscopy

À̸§ : (ÁÖ)ºí·çÇò

2019-12-26 10:47:42 Á¶È¸ :3206


Ghost Imaging Speeds Up Super-Resolution Microscopy

New nanoscopy approach poised to capture biological processes occurring inside cells at submillisecond speeds


¿ö½ÌÅÏ — ¿¬±¸¿øµéÀº Àü·Ê¾ø´Â ¼Óµµ·Î ÃÊ °íÇØ»óµµ Çö¹Ì°æÀ» ¾ò±â À§ÇØ °í±Þ À̹Ì¡ ¹æ½ÄÀ» »ç¿ëÇß½À´Ï´Ù. »õ·Î¿î ¹æ¹ýÀº ÀÌÀü¿¡´Â ºÒ°¡´ÉÇß´ø ¼Óµµ·Î »ì¾ÆÀÖ´Â ¼¼Æ÷¿¡¼­ ¹ß»ýÇÏ´Â °úÁ¤ÀÇ ¼¼ºÎ »çÇ×À» Æ÷ÂøÇÒ ¼ö ÀÖµµ·Ï ÇØ¾ß ÇÕ´Ï´Ù.

nanoscopy¶ó°íµµ ÇÏ´Â ÃÊ ÇØ»óµµ ±â¼úÀº ºûÀÇ È¸Àý ÇѰ踦 ±Øº¹ÇÏ¿© ³ª³ë ½ºÄÉÀÏ Çػ󵵸¦ ´Þ¼ºÇÕ´Ï´Ù. ³ª³ë Çö¹Ì°æÀº ¼¼Æ÷ ³»ºÎÀÇ °³º° ºÐÀÚÀÇ À̹ÌÁö¸¦ ĸó ÇÒ ¼ö ÀÖÁö¸¸ À̹ÌÁö¸¦ À籸¼ºÇÏ´Â µ¥ ¼ö¹é ¶Ç´Â ¼öõ °³ÀÇ À̹Ì¡ ÇÁ·¹ÀÓÀÌ ÇÊ¿äÇϱ⠶§¹®¿¡ »ì¾ÆÀÖ´Â ¼¼Æ÷¿¡ »ç¿ëÇϱⰡ ¾î·Æ½À´Ï´Ù. ºü¸£°Ô º¯È­ÇÏ´Â ¿ªÇÐÀ» ĸóÇϱ⿡´Â ³Ê¹« ´À¸³´Ï´Ù.

ĸ¼Ç : ¿¬±¸¿øµéÀº 60 ³ª³ë ¹ÌÅÍ ¸µ (»ðÀÔ µÈ)À» À̹Ì¡Çϱâ À§ÇØ »õ·Î¿î ³ª³ë ½ºÄÚÇÁ Á¢±Ù ±â¼úÀ» Å×½ºÆ®Çß½À´Ï´Ù. »õ·Î¿î nanoscopy Á¢±Ù¹ýÀº ´Ü 10 °³ÀÇ À̹ÌÁö ÇÁ·¹ÀÓÀ» »ç¿ëÇÏ¿© ¸µÀ» ÇØ°áÇÒ ¼öÀÖ´Â ¹Ý¸é ±âÁ¸ÀÇ Á¢±Ù¹ýÀº µ¿ÀÏÇÑ °á°ú¸¦ ¾ò±â À§ÇØ ÃÖ´ë 4000 ÇÁ·¹ÀÓÀÌ ÇÊ¿äÇß½À´Ï´Ù.

Credit:  Zhongyang Wang, Chinese Academy of Sciences

Áß±¹ °úÇÐ ¾ÆÄ«µ¥¹ÌÀÇ °í ¿µÇâµµ ¿¬±¸¸¦ À§ÇÑ ±¤ÇÐ Çùȸ (Optical Society 's, OSA ) Àú³Î ÀΠOptica¿¡¼­ , °í½ºÆ® À̹Ì¡ (Ghost Imaging)À¸·Î ¾Ë·ÁÁø ±âÁ¸ÀÇ À̹Ì¡ ±â¹ýÀ» »ç¿ëÇÏ¿© ³ª³ë ½ºÄÚÇÁÀÇ À̹Ì¡ ¼Óµµ¸¦ Çâ»ó½ÃÅ°´Â ¹æ¹ýÀ» ¼³¸íÇÕ´Ï´Ù. ÀÌ Á¶ÇÕÀº ÀüÅëÀûÀÎ ³ª³ë ½ºÄÚÇÇ ±â¼úº¸´Ù ¸î ¹è³ª ÀûÀº ¼öÀÇ À̹Ì¡ ÇÁ·¹ÀÓÀ» »ç¿ëÇÏ¿© ³ª³ë¹ÌÅÍ Çػ󵵸¦ »ý¼ºÇÕ´Ï´Ù.

"¿ì¸®ÀÇ À̹Ì¡ ¹æ¹ýÀº ¼ö½Ê ³ª³ë¹ÌÅÍÀÇ °ø°£ ºÐÇØ´É (»ý¹°ÇÐÀû °úÁ¤ÀÌ ÀϾ´Â °ø°£Àû ¹× ½Ã°£Àû ºÐÇØ´É)À» °¡Áø ¼¼Æ÷ ±¸Á¶¿¡¼­ ¹Ð¸® ÃÊ ½Ã°£ ´ÜÀ§·Î ¹ß»ýÇÏ´Â ¿ªÇÐÀ» °ËÃâÇÒ ¼ö ÀÖ´Ù."¶ó°í ¿¬±¸ÆÀÀÇ °øµ¿ ¸®´õÀÎ Zhongyang WangÀº ¸»Çß´Ù.

Combining techniques for faster imaging

»õ·Î¿î Á¢±Ù ¹æ½ÄÀÇ ±â¹ÝÀÎ STORM(stochastic optical reconstruction microscopy)Àº 2014 ³â ³ëº§»óÀ» ¼ö»óÇÑ 3°¡Áö ÃÊ ÇØ»óµµ ±â¼ú Áß Çϳª·Î, PALM (photoactivated localization microscopy)À̶ó°íµµÇÑ´Ù. 

STORMÀº ¹ß±¤ (ÄÑÁü) »óÅÂ¿Í ¾îµÎ¿î (²¨Áü) »óŸ¦ ÀüȯÇÏ´Â Çü±¤ ·¹À̺íÀ» »ç¿ëÇÏ´Â ±¤ ½Ã¾ß ±â¼úÀÔ´Ï´Ù.

ÁÖ¾îÁø ½Ã°£ ³», Çü±¤ ·¹À̺íÀÇ ÇÏÀ§ ¼¼Æ®¸¦ °¢°¢ ĸóÇÏ´Â ¼ö¹é, ¼öõ °³ÀÇ ½º³À ¼¦À¸·Î °¢°¢ÀÇ ºÐÀÚÀÇ À§Ä¡°¡ °áÁ¤µÇ°í Çü±¤ À̹ÌÁö¸¦ À籸¼ºÇϴµ¥ »ç¿ëµÈ´Ù.

¿¬±¸¿øµéÀº STORM À̹Ì¡ ÇÁ·Î¼¼½ºÀÇ ¼Óµµ¸¦ ³ôÀ̱â À§ÇØ °í½ºÆ® À̹Ì¡À¸·Î ÀüȯÇß½À´Ï´Ù. °í½ºÆ® À̹Ì¡Àº ¹°Ã¼¿Í »óÈ£ ÀÛ¿ëÇÏ´Â ºû ÆÐÅÏ°ú ±×·¸Áö ¾ÊÀº ÂüÁ¶ ÆÐÅÏÀ» ¿¬°ü½ÃÄÑ À̹ÌÁö¸¦ Çü¼ºÇÕ´Ï´Ù. °³º°ÀûÀ¸·Î ºû ÆÐÅÏÀº ¹°Ã¼¿¡ ´ëÇÑ ÀÇ¹Ì ÀÖ´Â Á¤º¸¸¦ Àü´ÞÇÏÁö ¾Ê½À´Ï´Ù. ¶ÇÇÑ ¿¬±¸¿øµéÀº ´©¶ôµÈ Á¤º¸¸¦ ä¿ì±â À§ÇØ ¾Ë°í¸®ÁòÀ» »ç¿ëÇϱ⠶§¹®¿¡ ³ëÃâÀ» ÁÙÀ̸鼭 À̹ÌÁö¸¦ À籸¼º ÇÒ ¼ö ÀÖ´Â °è»ê ¹æ½ÄÀÎ ¾ÐÃà À̹Ì¡À» »ç¿ëÇß½À´Ï´Ù.

ÇÑ ShengM ¿¬±¸¿øÀº¡°STORMÀº Àú¹Ðµµ Çü±¤ ¶óº§°ú ¸¹Àº À̹ÌÁö ÇÁ·¹ÀÓÀ» ÇÊ¿ä·Î ÇÏÁö¸¸ ¸Å¿ì ÀûÀº ¼öÀÇ ÇÁ·¹ÀÓ°ú °í¹Ðµµ Çü±¤ ´ÜÀ» »ç¿ëÇÏ¿© °íÇØ»óµµ À̹ÌÁö¸¦ ¸¸µé ¼ö ÀÖ½À´Ï´Ù. "¶ÇÇÑ º¹ÀâÇÑ Á¶¸íÀÌ ÇÊ¿äÇÏÁö ¾Ê¾Æ ¿ªµ¿ÀûÀÎ »ý¹°ÇÐÀû °úÁ¤°ú »ì¾ÆÀÖ´Â ¼¼Æ÷¿¡ Çظ¦ ³¢Ä¥ ¼ö ÀÖ´Â ±¤Ç¥¹é°ú ±¤µ¶¼ºÀ» ÁÙÀÏ ¼ö ÀÖ½À´Ï´Ù."

Improving imaging efficiency

»õ·Î¿î ±â¼úÀ» ±¸ÇöÇϱâ À§ÇØ ¿¬±¸ÁøÀº ·£´ý À§»ó º¯Á¶±â (random phase modulator)·Î ¾Ë·ÁÁø ±¤ÇÐ ºÎÇ°À» »ç¿ëÇÏ¿© »ùÇÿ¡¼­ Çü±¤À» ·£´ý ½ºÆå Ŭ ÆÐÅÏÀ¸·Î ¹Ù²Ù¾ú´Ù. ÀÌ·¯ÇÑ ¹æ½ÄÀ¸·Î Çü±¤À» ÄÚµùÇÏ¸é ¸Å¿ì ºü¸¥ CMOS Ä«¸Þ¶óÀÇ °¢ Çȼ¿ÀÌ ´ÜÀÏ ÇÁ·¹ÀÓ¿¡¼­ Àüü ¹°Ã¼·ÎºÎÅÍ ºûÀÇ ¼¼±â¸¦ ¼öÁýÇÒ ¼ö ÀÖ¾ú½À´Ï´Ù. °í½ºÆ® À̹Ì¡ ¹× ¾ÐÃà À̹Ì¡À» ÅëÇØ À̹ÌÁö¸¦ Çü¼ºÇϱâ À§ÇØ, ÀÌ ±¤ °­µµ´Â ´ÜÀÏ ´Ü°è¿¡¼­ ±âÁØ ±¤ ÆÐÅÏ°ú »ó°üµÇ¾ú´Ù. °á°úÀûÀ¸·Î º¸´Ù È¿À²ÀûÀÎ À̹ÌÁö ȹµæ°ú °íÇØ»óµµ À̹ÌÁö¸¦ Çü¼ºÇÏ´Â µ¥ ÇÊ¿äÇÑ ÇÁ·¹ÀÓ ¼ö°¡ ÁÙ¾îµì´Ï´Ù.

ĸ¼Ç : Áß±¹ °úÇпø (Chinese Academy of Sciences)ÀÇ ¿¬±¸ÆÀÀº °í½ºÆ® À̹Ì¡À» »ç¿ëÇÏ¿© ±âÁ¸ÀÇ ³ª³ë ½ºÄÚÇÇ ±â¼úº¸´Ù ÈξÀ ÀûÀº ¼öÀÇ À̹Ì¡ ÇÁ·¹ÀÓÀ» »ç¿ëÇÏ¿© ³ª³ë ¹ÌÅÍ ÇØ»óµµÀÇ ³ª³ë ½ºÄÚÇǸ¦ ´Þ¼ºÇß½À´Ï´Ù. ÀÌ ¹æ¹ýÀº ¸Å¿ì ³ôÀº ºÐÇØ´ÉÀ» °¡Áø ¼¼Æ÷ ÇÏ ±¸Á¶¿¡¼­ ¹Ð¸® ÃÊ ½Ã°£ ´ÜÀ§·Î ¹ß»ýÇÏ´Â ¿ªÇÐÀ» Á¶»çÇÏ´Â µ¥ »ç¿ëµÉ ¼ö ÀÖ½À´Ï´Ù.

Credit:  Zhongyang Wang, Chinese Academy of Sciences

¿¬±¸¿øµéÀº ÀÌ ±â¼úÀ» »ç¿ëÇÏ¿© 60 ³ª³ë¹ÌÅÍ ¸µÀ» À̹Ì¡ ÇÏ¿© Å×½ºÆ®Çß½À´Ï´Ù. »õ·Î¿î nanoscopy Á¢±Ù¹ýÀº ´Ü 10 °³ÀÇ À̹ÌÁö ÇÁ·¹ÀÓÀ» »ç¿ëÇÏ¿© ¸µÀ» ÇØ°áÇÒ ¼ö ÀÖ´Â ¹Ý¸é, ÀüÅëÀûÀÎ STORM Á¢±Ù¹ýÀº µ¿ÀÏÇÑ °á°ú¸¦ ´Þ¼ºÇϱâ À§ÇØ ÃÖ´ë 4000 ÇÁ·¹ÀÓÀÌ ÇÊ¿äÇß½À´Ï´Ù. »õ·Î¿î Á¢±Ù ¹æ½ÄÀº ¶ÇÇÑ 100 °³ÀÇ À̹ÌÁö ÇÁ·¹ÀÓÀÌ ÀÖ´Â 40 ³ª³ë¹ÌÅÍ ´«±ÝÀÚ¸¦ ÇØ°áÇß½À´Ï´Ù.

WangÀº¡°ÀÌ ¹æ¹ýÀÌ ÀÌ ¿¬±¸¿¡ »ç¿ëµÈ °Íº¸´Ù ¾àÇÑ Çü±¤À» ³ªÅ¸³»´Â °ÍÀ» Æ÷ÇÔÇÏ¿© ´Ù¾çÇÑ Çü±¤ ½Ã·á¿¡ Àû¿ëµÉ ¼ö Àֱ⸦ Èñ¸ÁÇÑ´Ù"¶ó°í ¸»Çß´Ù. ¶ÇÇÑ ¿¬±¸¿øµéÀº ÀÌ ±â¼úÀ» ´õ ºü¸¥ ½Ã¾ß·Î ºñµð¿À ·¹ÀÌÆ® À̹Ì¡À» ´Þ¼ºÇÏ°í 3D ¹× Ä÷¯ À̹ÌÁö¸¦ ȹµæÇÏ´Â µ¥ »ç¿ëÇÒ °èȹÀÔ´Ï´Ù.

³í¹® : W. Li, Z. Tong, K. Xiao, Z. Liu, Q. Gao, J. Sun, S. Liu, S. Han, Z. Wang,¡°°í½ºÆ® À̹Ì¡ ±â¹ÝÀÇ ´ÜÀÏ ÇÁ·¹ÀÓ ±¤ ½Ã¾ß ³ª³ë ½ºÄÚÇÁ Èñ¼Ò¼º Á¦¾àÀ» ÅëÇØ¡±¡± Optica , 6, 12, 1515-1523 (2019).
DOI : https://doi.org/10.1364/OPTICA.6.001515


Ãâó: https://www.osa.org/en-us/about_osa/newsroom/news_releases/2019/ghost_imaging_speeds_up_super-esolution_microscop/


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